Circuit of biology

The studies carried out as part of the CONECT-AML project require the use of biological samples (bone marrow and blood) collected at the time of diagnosis.

For patients included in  MyeChild01 therapeutic protocol, samples are systematically centralized to perform diagnostic molecular analyzes on two hospital laboratories (Paris-Trousseau and Lille).

The flow of these protocol samples from the 28 investigative centers is managed by biological coordinators who can value in real time, any additional aliquot and /or residue of samples that may be available for CONECT-AML, if the parents have accepted this provision mentioned on the informed consent.

Thus, the route and the use of biological samples are rationalized: centralized grouping (“MyeChild01 shuttle”) with priority to stratifying protocol analyzes and synergies with the various research teams involved.

1.       What are the priority samples?

  • The samples required to establish the diagnosis are priority.
  • They will enable to carry out locally: cytology, cytogenetics (heparinized tube), diagnostic immunophenotyping (EDTA tube)
  • Any sample not used for the diagnosis can be kept locally for later reuse in the context of research (specific consent)

2.      What are the protocol samples for molecular stratification and monitoring in MyeChild01?

  • Bone marrow samples (EDTA tube) and blood (EDTA tube and dry tube) must be sent at diagnosis, then at follow-up in one of the two referent laboratories (Lille or Trousseau Paris)

3.     What are the samples required for CONECT-AML?

  • An additional BM sample (EDTA tube) and a blood sample (EDTA tube) can be drawn and sent with MyeChild01 protocol samples in the MyeChild01 referent laboratory.
  • The referent MyeChild01 laboratory is in charge of the distribution of the samples to the different CONECT-AML teams.
  • For the centers in Lyon, Marseille, Robert Debré (Paris), Trousseau (Paris), and any other team wishing to do so, an additional direct shipment to Lyon team will be proposed.

4.      Who provides transportation?

  • Transportation is provided free of charge to the referent laboratories
  • An additional transporter is planned for direct shipments to Lyon research teams

5.       Who coordinates and sends biological resources?

  • For any question relating to biological samples (which tubes, which quantities, which destinations, etc.), contact: Emmanuelle Delabesse ( )
  • Other contacts: Audrey Guilmatre, Maxime Ferreboeuf (Clinical research team in Trousseau Hospital: ), Hélène Lapillonne, Arnaud Petit