Team 7- Genetics and modelization of childhood leukemia

Attachment structures:

INSERM, Institut Gustave Roussy, Université Paris Saclay

Adress : Institut Gustave Roussy, INSERM U1170, 39 rue Camille Desmoulins, Pavillon de recherche 2, Pièce 342, 94800 Villejuif

Team website : Voir le site See here

CONECT-AML  project leader in this team :

Other project participants in the team :

  • Cécile LOPEZ, Ingénieur de recherche
  • Zakia AID, Ingénieur d’étude

Project summary :

We are studying the involved molecular mechanisms by the mutations found in childhood leukemia cells in order to define new therapeutic approaches to specifically target them. For this, we are developing models for the most aggressive mutations either directly from patient cells (PDX: patient-derived xenograft) or from expression of mutations in normal cells on which we carry out functional and preclinical studies