Our projects

From March 2005 to December 2011, 441 children and adolescents with acute myeloid leukemia were treated in the ELAM02 therapeutic protocol (Multicentric protocol for the treatment of acute myeloid leukemia in children and adolescents. Randomized study of a maintenance treatment with Interleukin 2).

The clinical and research teams, several of which being part of CONECT-AML, allowed to carry out several projects whosepublications are mentioned below.

In the “Research teams” section, the individual contributions of CONECT-AML members are accessible via their ORCID identifiers, Researcher ID, Research Gate, etc


Clinical results of ELAM02 protocol

Article original : Cytogenetics and outcome of allogeneic transplantation in first remission of acute myeloid leukemia: the French pediatric experience, Bone Marrow Transplant, 2017, 52, 516-521, Alloin, AL ; Leverger, G ; Dalle, JH ; Galambrun, C ; Bertrand, Y ; Baruchel, A & al


Article original : Acute megakaryoblastic leukemia (excluding Down syndrome) remains an acute myeloid subgroup with inferior outcome in the French ELAM02 trial, Pediatr Hematol Oncol, 2017, 34, 425-427, Teyssier, AC ; Lapillonne, H ; Pasquet, M ; Ballerini, P ; Baruchel, A ; Ducassou, S & al ,


Article original : Maintenance Therapy With Interleukin-2 for Childhood AML: Results of ELAM02 Phase III Randomized Trial. HemaSphere, 2018;2:1. Petit A, Ducassou S, Leblanc T, Pasquet M, Rousseau A, Ragu C, & al


Article original : GLeukemia Cutis in Childhood Acute Myeloid Leukemia: Epidemiological, Clinical, Biological, and Prognostic Characteristics of Patients Included in the ELAM02 Study. HemaSphere, 2018;2:5.ouache E, Greze V, Strullu M, Saultier P, Fenneteau O, Gandemer V, & al

Biology of Leukemias

Article original : Invasive Fungal Infections in Pediatric Acute Myelogenous LeukemiaPediatr Infect Dis J, 2015, 34, 1262-4, Ducassou, S ; Rivaud, D ; Auvrignon, A ; Vérité, C ; Bertrand, Y ; Gandemer, V & al

Article original : Comprehensive mutational profiling of core binding factor acute myeloid leukemia, Blood, 2016, 127, 2451-9, Duployez, N ; Marceau-Renaut, A ; Boissel, N ; Petit, A ; Bucci, M ; Geffroy, S & al


Article original : ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia, Cancer Cell, 2017, 31, 452-465, Thirant, C ; Ignacimouttou, C ; Lopez, CK ; Diop, M ; Le Mouël, L ; Thiollier, C & al


Article original : NUP98 is rearranged in 3.8% of pediatric AML forming a clinical and molecular homogenous group with a poor prognosis, Leukemia, 2017, 31, 565-572, Struski, S ; Lagarde, S ; Bories, P ; Puiseux, C ; Prade, N ; Cuccuini, W & al


Article original : Molecular Profiling Defines Distinct Prognostic Subgroups in Childhood AML: A Report From the French ELAM02 study group. HemaSphere, 2018;2:1.  Marceau-Renaut A, Duployez N, Ducourneau B, Labopin M, Petit A, Rousseau A, & al,


Article original : Ontogenic changes in hematopoietic hierarchy determine pediatric specificity and disease phenotype in fusion oncogene-driven myeloid leukemia. Cancer Discovery, October 29, 2019. Mercher.T; Schwaller.J & al


Article original : The stem cell-associated gene expression signature allows risk stratification in pediatric acute myeloid leukemia. Leukemia. 2019 Feb;33(2):348-357. doi: 10.1038/s41375-018-0227-5. Epub 2018 Aug 8.Duployez N, Marceau-Renaut A, Villenet C, Petit A, Rousseau A, Ng SWK, Paquet A, Gonzales F, Barthélémy A, Leprêtre F, Pottier N, Nelken B, Michel G, Baruchel A, Bertrand Y, Leverger G, Lapillonne H, Figeac M, Dick JE, Wang JCY, Preudhomme C, Cheok M

Long term followup

Article original : Metabolic syndrome in adults who received hematopoietic stem cell transplantation for acute childhood leukemia: an LEA study, Bone Marrow Transplant, 2015, 50, 1438-44,Oudin, C ; Auquier, P ; Bertrand, Y ; Contet, A ; Kanold, J ; Sirvent, N & al


Article original : Cohort Profile: the French childhood cancer survivor study for leukaemia (LEA Cohort), Int J Epidemiol, 2015, 44, 49-57, Berbis, J ; Michel, G ; Baruchel, A ; Bertrand, Y ; Chastagner, P ; Demeocq, F & al


Article original : Late thyroid complications in survivors of childhood acute leukemia. An L.E.A. study, Haematologica, 2016, 101, 747-56,Oudin, C ; Auquier, P ; Bertrand, Y ; Chastagner, P ; Kanold, J ; Poirée, M & al


Article original : Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A. study, Haematologica, 2016, 101, 1603-1610, Saultier, P ; Auquier, P ; Bertrand, Y ; Vercasson, C ; Oudin, C ; Contet, A & al


Article original : The Impact of Donor Type on Long-Term Health Status and Quality of Life after Allogeneic Hematopoietic Stem Cell Transplantation for Childhood Acute Leukemia: A Leucémie de l’Enfant et de L’Adolescent Study, Biol Blood Marrow Transplant, 2016, 22, 2003-2010, Visentin, S ; Auquier, P ; Bertrand, Y ; Baruchel, A ; Tabone, MD ; Pochon, C & al


Article original : Prevalence and risk factors of iron overload after hematopoietic stem cell transplantation for childhood acute leukemia: a LEA study, Bone Marrow Transplant, 2017, 52, 80-87, Sirvent, A ; Auquier, P ; Oudin, C ; Bertrand, Y ; Bohrer, S ; Chastagner, P & al