Attachment structures :
Centre de Recherche en Cancérologie de Lyon-CRCL
Inserm U1052-CNRS UMR5286
Université Claude Bernard Lyon 1
Adress :
CRCL, U1052-UMR5286, Centre Léon Bérard, Bat Cheney D, 28 Rue Laennec, 69373 Lyon, France
Team website : See here
CONECT-AML project leader in this team :
- Véronique MAGUER-SATTA, Directrice de recherche
- ORCID: 0000-0002-1556-068X
Other project participants in the team :
- Sylvain LEFORT, Post-doctorant
- ORCID: 0000-0001-7320-4256
- Kevin GEISTLICH, Assistant Ingénieur
- Sandrine JEANPIERRE, Technicienne
Project summary:
We compare the leukemic microenvironment of pediatric AML bone marrow versus healthy tissue. For this, we characterize the content of the bone marrow in leukemic stem cells (LSC) and cellular components of the tumor microenvironment (stromal and immune cells). Our team will study in more detail the anomalies of the BMP pathway in the LSC’s dialogue with the other cells of its microenvironment, in particularly the mesenchymal stem cells.
