Team 8- Niche and cancer in hematopoiesis

Attachment structures :

INSERM/CEA/P7/P11 Unité «Stabilité Génétique, Cellules Souches et Radiations”

Adress : Institut de RadioBiologie Cellulaire et Moléculaire, CEA, 18 route du panorama, 92260, Fontenay-aux-roses

Team website : See here

CONECT-AML  project leader in this team :

Other project participants in the team :

  • Laurent RENOU, Ingénieur de recherche
  • Marie-Laure ARCANGELI, Chargée de recherche, CR1

Summary of the project  :

Within CONECT-AML, we participate in the development of xenograft models in order to expand the leukemic samples from affected children, and therefore to obtain significant quantities of material to improve the study of the genetic / epigenetic modifications involved in the development of these pathologies. Xenograft models are made available for the network in order to test new therapeutic strategies. In this network, we are exploring new transplant protocols and new murine recipients. We also participate in the modeling of leukemias of the megakaryocytic line when oncogenic events have been identified by genetically manipulating normal human hematopoietic cells. These different models contribute to the understanding of leukemic development and offer the possibility of drug testing.